Thermogenics are compounds designed to amplify body heat production, thereby increasing energy expenditure and promoting weight loss. One such compound is epigallocatechin gallate, also known as EGCG. EGCG has been theorized to increase energy expenditure by stimulating brown adipose tissue thermogenesis. In support of this theory, Dulloo et al. reported that EGCG in combination with caffeine (e.g., 50 mg caffeine and 90 mg epigallocatechin gallate taken three times per day) significantly increased 24-hour energy expenditure and fat utilization in humans to a much greater extent than when an equivalent amount of caffeine was evaluated, suggesting a synergistic effect. Recently, Di Pierro et al. reported that the addition of EGCG to a hypocaloric diet resulted in a significant increase in weight loss (14 kg vs. 5 kg) versus a hypocaloric diet alone over a 90-day clinical trial. Theoretically, the increases in energy expenditure via EGCG supplementation may help individuals lose weight and/or manage body composition.
A second thermogenic compound in ThermoFuel V9 is cayenne pepper. Studies suggest that chemical compounds in cayenne have the ability to increase the body's heat production, thus increasing the rate of metabolism of fats and carbohydrates. Additional research also indicates that cayenne increases the production of epinephrine and norepinephrine, which together decrease appetite. For dieters, it has been suggested that adding cayenne to a day's diet reduces hunger after meals and reduces calories consumed during subsequent meals.
The last thermogenic compound added in ThermoFuel V9 is the patented compound Advantra Z®. Because Advantra Z® contain synephrine, it is able to stimulate thermogenesis, increase lipolysis to facilitate the burning of fats for fuel, reduce weight, increase lean muscle mass, and suppress appetite. Advantra Z® also improves athletic performance and uptake of amino acids into muscle cells. Advantra Z® offers many of the metabolic-enhancing effects of ephedrine without the dangerous side effects. Unlike ephedrine, Advantra Z® does not influence alpha-1, alpha-2, beta-1, or beta-2 receptors, which affect blood pressure and heart rate, making it a safe and effective tool for weight loss. Advantra Z® only stimulates beta-3 adrenergic receptors, which increase lipolysis in fat tissue and thermogenesis in skeletal muscle.